[HTML][HTML] The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
C Rust, LM Karnitz, CV Paya, J Moscat… - Journal of Biological …, 2000 - ASBMB
Liver injury during cholestasis reflects a balance between the effects of toxic and nontoxic
bile acids. However, the critical distinction between a toxic and nontoxic bile acid remains
subtle and unclear. For example, the glycine conjugate of chenodeoxycholate (GCDC)
induces hepatocyte apoptosis, whereas the taurine conjugate (TCDC) does not. We
hypothesized that the dissimilar cellular responses may reflect differential activation of a
phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway. In the bile acid …
bile acids. However, the critical distinction between a toxic and nontoxic bile acid remains
subtle and unclear. For example, the glycine conjugate of chenodeoxycholate (GCDC)
induces hepatocyte apoptosis, whereas the taurine conjugate (TCDC) does not. We
hypothesized that the dissimilar cellular responses may reflect differential activation of a
phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway. In the bile acid …