[HTML][HTML] RNA interference libraries prove their worth in hunt for tumor suppressor genes
J Downward - Cell, 2005 - cell.com
Cell, 2005•cell.com
RNA interference has been promoted as an ideal tool for functional genomics, but to date
the success stories have principally been in model organisms. Two papers in this issue of
Cell change all that: Westbrook et al.(2005) and Kolfschoten et al.(2005) use RNA
interference libraries targeting large proportions of the human genome to uncover two novel
tumor suppressor genes. REST is a transcriptional repressor that silences neuron-specific
gene expression, and PITX1 is a homeodomain transcription factor that promotes the …
the success stories have principally been in model organisms. Two papers in this issue of
Cell change all that: Westbrook et al.(2005) and Kolfschoten et al.(2005) use RNA
interference libraries targeting large proportions of the human genome to uncover two novel
tumor suppressor genes. REST is a transcriptional repressor that silences neuron-specific
gene expression, and PITX1 is a homeodomain transcription factor that promotes the …
RNA interference has been promoted as an ideal tool for functional genomics, but to date the success stories have principally been in model organisms. Two papers in this issue of Cell change all that: Westbrook et al. (2005) and Kolfschoten et al. (2005) use RNA interference libraries targeting large proportions of the human genome to uncover two novel tumor suppressor genes. REST is a transcriptional repressor that silences neuron-specific gene expression, and PITX1 is a homeodomain transcription factor that promotes the expression of a negative regulator of Ras.
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