Frequent allelic imbalance of tumor suppressor gene loci in cervical dysplasia
F Luft, J Gebert, A Schneider… - International journal …, 1999 - journals.lww.com
In addition to human papillomavirus (HPV) infection. loss of heterozy-gosity (LOH) at tumor
suppressor gene loci has been frequently observed in cervical cancer. Thus, it may be
assumed that detection and characterization of specific LOH profiles in preneoplastic
lesions, in addition to HPV typing, might facilitate assessment of progression risk of cervical
dysplasia. In this study. the type and frequency of allelic imbalance (allelic loss or allelic
reduction) were analyzed in 24 unrelated cervical lesions using 14 polymorphic …
suppressor gene loci has been frequently observed in cervical cancer. Thus, it may be
assumed that detection and characterization of specific LOH profiles in preneoplastic
lesions, in addition to HPV typing, might facilitate assessment of progression risk of cervical
dysplasia. In this study. the type and frequency of allelic imbalance (allelic loss or allelic
reduction) were analyzed in 24 unrelated cervical lesions using 14 polymorphic …