[HTML][HTML] Prostaglandin E2 stimulates the β-catenin/T cell factor-dependent transcription in colon cancer
J Shao, C Jung, C Liu, H Sheng - Journal of Biological Chemistry, 2005 - ASBMB
Cyclooxygenase and its derived prostaglandin E 2 (PGE 2) have been shown to stimulate
the growth of cancer cells and promote tumor angiogenesis. Here, we show that PGE 2
activated the β-catenin/T cell factor-dependent transcription in colon cancer cells through the
cAMP/protein kinase A pathway. The expression of cyclin D1 and vascular endothelial
growth factor was induced by PGE 2 in LS-174T cells. Moreover, PGE 2 and mutated β-
catenin stimulated the transcription of cyclin D1 and vascular endothelial growth factor in a …
the growth of cancer cells and promote tumor angiogenesis. Here, we show that PGE 2
activated the β-catenin/T cell factor-dependent transcription in colon cancer cells through the
cAMP/protein kinase A pathway. The expression of cyclin D1 and vascular endothelial
growth factor was induced by PGE 2 in LS-174T cells. Moreover, PGE 2 and mutated β-
catenin stimulated the transcription of cyclin D1 and vascular endothelial growth factor in a …