Pathology of mouse models of intestinal cancer: consensus report and recommendations
GP Boivin, K Washington, K Yang, JM Ward… - Gastroenterology, 2003 - Elsevier
GP Boivin, K Washington, K Yang, JM Ward, TP Pretlow, R Russell, DG Besselsen…
Gastroenterology, 2003•ElsevierThe marked diversity in the phenotype of intestinal neoplasia in murine models offers
opportunities to model many characteristics of human CRC, including tumor progression,
metastasis, gross morphology, and histology. However, the lack of a consistent model of
metastasis is of particular concern in developing mouse models of human CRC. AOM-
treated mice consistently develop metastasis, but the absence of control by known genetic
mutations under carcinogen treatment makes this model system less
opportunities to model many characteristics of human CRC, including tumor progression,
metastasis, gross morphology, and histology. However, the lack of a consistent model of
metastasis is of particular concern in developing mouse models of human CRC. AOM-
treated mice consistently develop metastasis, but the absence of control by known genetic
mutations under carcinogen treatment makes this model system less
Summary
The marked diversity in the phenotype of intestinal neoplasia in murine models offers opportunities to model many characteristics of human CRC, including tumor progression, metastasis, gross morphology, and histology. However, the lack of a consistent model of metastasis is of particular concern in developing mouse models of human CRC. AOM-treated mice consistently develop metastasis, but the absence of control by known genetic mutations under carcinogen treatment makes this model system less
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