A critical role for Pin1 in allergic pulmonary eosinophilia in rats
S Esnault, LA Rosenthal, ZJ Shen, JB Sedgwick… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Infiltration, accumulation, and degranulation of eosinophils in the lung are
hallmarks of active allergic asthma. The pulmonary response to inhaled allergen triggers the
secretion of eosinophil chemoattractants and antiapoptotic cytokines, including GM-CSF, IL-
3, IL-4, IL-5, and eotaxin, among others. We recently showed that in vitro Pin1 regulated
eosinophil production of and response to GM-CSF. OBJECTIVE: We sought to determine the
effect of Pin1 inhibition on pulmonary eosinophilia after allergen challenge. METHODS: The …
hallmarks of active allergic asthma. The pulmonary response to inhaled allergen triggers the
secretion of eosinophil chemoattractants and antiapoptotic cytokines, including GM-CSF, IL-
3, IL-4, IL-5, and eotaxin, among others. We recently showed that in vitro Pin1 regulated
eosinophil production of and response to GM-CSF. OBJECTIVE: We sought to determine the
effect of Pin1 inhibition on pulmonary eosinophilia after allergen challenge. METHODS: The …