[HTML][HTML] The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary αT3 cells by protein kinase Cα …
A Rose, P Froment, V Perrot, MJ Quon… - Journal of Biological …, 2004 - ASBMB
The luteinizing hormone-releasing hormone (LHRH) receptor is a G protein-coupled
receptor involved in the synthesis and release of pituitary gonadotropins and in the
proliferation and apoptosis of pituitary cells. Insulin-like growth factor-1 receptor (IGF-1R) is
a tyrosine kinase receptor that has a mitogenic effect on pituitary cells. In this study, we used
the αT3 gonadotrope cell line as a model to characterize the IGF-1R signaling pathways and
to investigate whether this receptor interacts with the LHRH cascade. We found that IGF-1 …
receptor involved in the synthesis and release of pituitary gonadotropins and in the
proliferation and apoptosis of pituitary cells. Insulin-like growth factor-1 receptor (IGF-1R) is
a tyrosine kinase receptor that has a mitogenic effect on pituitary cells. In this study, we used
the αT3 gonadotrope cell line as a model to characterize the IGF-1R signaling pathways and
to investigate whether this receptor interacts with the LHRH cascade. We found that IGF-1 …