Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in rats
RL Sorkness, JL Remus, LA Rosenthal - Journal of allergy and clinical …, 2004 - Elsevier
BACKGROUND: Metered-dose inhalers (MDIs) are convenient, simple, inexpensive, and
reproducible devices for administering aerosolized drugs through the pulmonary route, but
methods have not been available for use of these devices in small animals. OBJECTIVE: We
sought to test the efficacy of delivery of fluticasone through an MDI to rats with a rodent-
adapted spacer chamber and to compare this treatment with systemic dexamethasone for
the acute pulmonary allergic inflammatory response. METHODS: Changes in body and …
reproducible devices for administering aerosolized drugs through the pulmonary route, but
methods have not been available for use of these devices in small animals. OBJECTIVE: We
sought to test the efficacy of delivery of fluticasone through an MDI to rats with a rodent-
adapted spacer chamber and to compare this treatment with systemic dexamethasone for
the acute pulmonary allergic inflammatory response. METHODS: Changes in body and …