[HTML][HTML] Reversible inhibition of α-synuclein fibrillization by dopaminochrome-mediated conformational alterations
Previous studies demonstrated that α-synuclein (α-syn) fibrillization is inhibited by
dopamine, and studies to understand the molecular basis of this process were conducted
(Conway, KA, Rochet, JC, Bieganski, RM, and Lansbury, PT, Jr.(2001) Science 294, 1346–
1349). Dopamine inhibition of α-syn fibrillization generated exclusively spherical oligomers
that depended on dopamine autoxidation but not α-syn oxidation, because mutagenesis of
Met, His, and Tyr residues in α-syn did not abrogate this inhibition. However, truncation of α …
dopamine, and studies to understand the molecular basis of this process were conducted
(Conway, KA, Rochet, JC, Bieganski, RM, and Lansbury, PT, Jr.(2001) Science 294, 1346–
1349). Dopamine inhibition of α-syn fibrillization generated exclusively spherical oligomers
that depended on dopamine autoxidation but not α-syn oxidation, because mutagenesis of
Met, His, and Tyr residues in α-syn did not abrogate this inhibition. However, truncation of α …