[HTML][HTML] The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human …
R Sewell, M Bäckström, M Dalziel… - Journal of Biological …, 2006 - ASBMB
The functional properties of glycoproteins are strongly influenced by their profile of
glycosylation, and changes in this profile are seen in malignancy. In mucin-type O-linked
glycosylation these changes can result in the production of mucins such as MUC1, carrying
shorter sialylated O-glycans, and with different site occupancy. Of the tumor-associated
sialylated O-glycans, the disaccharide, sialyl-Tn (sialic acid α2, 6GalNAc), is expressed by
30% of breast carcinomas and is the most tumor-specific. The ST6GalNAc-I …
glycosylation, and changes in this profile are seen in malignancy. In mucin-type O-linked
glycosylation these changes can result in the production of mucins such as MUC1, carrying
shorter sialylated O-glycans, and with different site occupancy. Of the tumor-associated
sialylated O-glycans, the disaccharide, sialyl-Tn (sialic acid α2, 6GalNAc), is expressed by
30% of breast carcinomas and is the most tumor-specific. The ST6GalNAc-I …