Murine psoriasis-like disorder induced by naive CD4+ T cells

MP SchÖn, M Detmar, CM Parker - Nature medicine, 1997 - nature.com
MP SchÖn, M Detmar, CM Parker
Nature medicine, 1997nature.com
Psoriasis is a complex disorder involving alterations of many cell types. Although evidence
suggests a T-cell pathogenesis for psoriasis, a primary role of T cells has not been directly
demonstrated. Here, we show that reconstitution of scid/scid mice with minor
histocompatibility mismatched naive CD4+ T lymphocytes resulted in skin alterations that
strikingly resembled human psoriasis clinically, histopathologically and in cytokine
expression. This skin disorder was diminished when memory T cells were coinjected. Thus …
Abstract
Psoriasis is a complex disorder involving alterations of many cell types. Although evidence suggests a T-cell pathogenesis for psoriasis, a primary role of T cells has not been directly demonstrated. Here, we show that reconstitution of scid/scid mice with minor histocompatibility mismatched naive CD4+ T lymphocytes resulted in skin alterations that strikingly resembled human psoriasis clinically, histopathologically and in cytokine expression. This skin disorder was diminished when memory T cells were coinjected. Thus, a subset of dysregulated CD4+ T cells can cause tissue alterations seen in psoriasis without the presence of CD8+ cells or a primary epithelial abnormality.
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