Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
V Hirsch-Reinshagen, S Zhou, BL Burgess… - Journal of Biological …, 2004 - ASBMB
ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the
central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein
(HDL), where it mediates the efflux of cholesterol and phospholipids to apolipoprotein (apo)
AI. Deficiency of ABCA1 results in lack of circulating HDL and greatly reduced levels of apoA-
I. ABCA1 is also expressed in cells within the CNS, but its roles in brain lipid metabolism are
not yet fully understood. In the brain, glia synthesize the apolipoproteins involved in CNS …
central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein
(HDL), where it mediates the efflux of cholesterol and phospholipids to apolipoprotein (apo)
AI. Deficiency of ABCA1 results in lack of circulating HDL and greatly reduced levels of apoA-
I. ABCA1 is also expressed in cells within the CNS, but its roles in brain lipid metabolism are
not yet fully understood. In the brain, glia synthesize the apolipoproteins involved in CNS …
