[HTML][HTML] The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
V Hirsch-Reinshagen, LF Maia, BL Burgess… - Journal of Biological …, 2005 - ASBMB
ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be
required to maintain normal apoE levels and lipidation in the central nervous system. In
addition, ABCA1 has been reported to modulate β-amyloid (Aβ) production in vitro. These
observations raise the possibility that ABCA1 may play a role in the pathogenesis of
Alzheimer disease. Here we report that the deficiency of ABCA1 does not affect soluble or
guanidine-extractable Aβ levels in Tg-SwDI/B or amyloid precursor protein/presenilin 1 …
required to maintain normal apoE levels and lipidation in the central nervous system. In
addition, ABCA1 has been reported to modulate β-amyloid (Aβ) production in vitro. These
observations raise the possibility that ABCA1 may play a role in the pathogenesis of
Alzheimer disease. Here we report that the deficiency of ABCA1 does not affect soluble or
guanidine-extractable Aβ levels in Tg-SwDI/B or amyloid precursor protein/presenilin 1 …
