Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-β peptide levels in vivo
V Hirsch-Reinshagen, JY Chan, A Wilkinson… - Journal of lipid …, 2007 - ASBMB
ABCA1-deficient mice have low levels of poorly lipidated apolipoprotein E (apoE) and
exhibit increased amyloid load. To test whether excess ABCA1 protects from amyloid
deposition, we crossed APP/PS1 mice to ABCA1 bacterial artificial chromosome (BAC)
transgenic mice. Compared with wild-type animals, the ABCA1 BAC led to a 50% increase
in cortical ABCA1 protein and a 15% increase in apoE abundance, demonstrating that this
BAC supports modest ABCA1 overexpression in brain. However, this was observed only in …
exhibit increased amyloid load. To test whether excess ABCA1 protects from amyloid
deposition, we crossed APP/PS1 mice to ABCA1 bacterial artificial chromosome (BAC)
transgenic mice. Compared with wild-type animals, the ABCA1 BAC led to a 50% increase
in cortical ABCA1 protein and a 15% increase in apoE abundance, demonstrating that this
BAC supports modest ABCA1 overexpression in brain. However, this was observed only in …
