ATP-binding cassette transporter AI and its role in HDL formation
Initial lipidation of apoA-I by hepatic ABCA1 is critical for plasma HDL formation because it
enables pre-β HDL to function more efficiently as a cholesterol acceptor for other pathways
of cholesterol efflux in the reverse cholesterol transport pathway and prevents apoA-I from
rapidly associating with preexisting plasma HDL particles, resulting in greater availability of
pre-β HDL particles for cholesterol efflux.
enables pre-β HDL to function more efficiently as a cholesterol acceptor for other pathways
of cholesterol efflux in the reverse cholesterol transport pathway and prevents apoA-I from
rapidly associating with preexisting plasma HDL particles, resulting in greater availability of
pre-β HDL particles for cholesterol efflux.
Summary
Initial lipidation of apoA-I by hepatic ABCA1 is critical for plasma HDL formation because it enables pre-β HDL to function more efficiently as a cholesterol acceptor for other pathways of cholesterol efflux in the reverse cholesterol transport pathway and prevents apoA-I from rapidly associating with preexisting plasma HDL particles, resulting in greater availability of pre-β HDL particles for cholesterol efflux.
Lippincott Williams & Wilkins