Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Aβ levels
H Fukumoto, A Deng, MC Irizarry, ML Fitzgerald… - Journal of Biological …, 2002 - ASBMB
The expression, function, and regulation of the cholesterol efflux molecule, ABCA1, has
been extensively examined in peripheral tissues but only poorly studied in the brain. Brain
cholesterol metabolism is of interest because several lines of evidence suggest that
elevated cholesterol increases the risk of Alzheimer's disease. We found a largely neuronal
expression of ABCA1 in normal rat brain by in situ hybridization. ABCA1 message was
dramatically up-regulated in neurons and glia in areas of damage by hippocampal AMPA …
been extensively examined in peripheral tissues but only poorly studied in the brain. Brain
cholesterol metabolism is of interest because several lines of evidence suggest that
elevated cholesterol increases the risk of Alzheimer's disease. We found a largely neuronal
expression of ABCA1 in normal rat brain by in situ hybridization. ABCA1 message was
dramatically up-regulated in neurons and glia in areas of damage by hippocampal AMPA …
