[HTML][HTML] Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex
X Zhao, KA Carnevale, MK Cathcart - Journal of Biological Chemistry, 2003 - ASBMB
Phagocyte NADPH oxidase is critical for defense against pathogens and contributes to
inflammatory tissue injury. One component of the NADPH oxidase complex is the small GTP-
binding protein Rac. There are two isoforms of Rac, and Rac2 is the predominant isoform in
neutrophils and has been shown to be essential for NADPH oxidase activity. In primary
human monocytes we report that in contrast to neutrophils, Rac1 is the predominantly
expressed isoform. Upon monocyte activation by a variety of agents, we found that Rac1 …
inflammatory tissue injury. One component of the NADPH oxidase complex is the small GTP-
binding protein Rac. There are two isoforms of Rac, and Rac2 is the predominant isoform in
neutrophils and has been shown to be essential for NADPH oxidase activity. In primary
human monocytes we report that in contrast to neutrophils, Rac1 is the predominantly
expressed isoform. Upon monocyte activation by a variety of agents, we found that Rac1 …