[HTML][HTML] Fibrillar β-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia
B Wilkinson, J Koenigsknecht-Talboo… - Journal of Biological …, 2006 - ASBMB
Microglial interaction with extracellular β-amyloid fibrils (fAβ) is mediated through an
ensemble of cell surface receptors, including the B-class scavenger receptor CD36, the α 6
β 1-integrin, and the integrin-associated protein/CD47. The binding of fAβ to this receptor
complex has been shown to drive a tyrosine kinase-based signaling cascade leading to
production of reactive oxygen species and stimulation of phagocytic activity; however, little is
known about the intracellular signaling cascades governing the microglial response to fAβ …
ensemble of cell surface receptors, including the B-class scavenger receptor CD36, the α 6
β 1-integrin, and the integrin-associated protein/CD47. The binding of fAβ to this receptor
complex has been shown to drive a tyrosine kinase-based signaling cascade leading to
production of reactive oxygen species and stimulation of phagocytic activity; however, little is
known about the intracellular signaling cascades governing the microglial response to fAβ …