The current future understanding of inflammatory bowel disease

DK Podolsky - Best practice & research Clinical gastroenterology, 2002 - Elsevier
Accumulating evidence indicates that the inflammatory bowel diseases result from an
activation of immune and inflammatory responses initiated by a stimulation of the luminal
flora or their products. Genetically determined variations in key mucosal functions, including
cell activation by prototypic bacterial pattern molecules, lead to differential susceptibility to
the development of these disorders, probably reflecting an interrelated activation of the
innate and adaptive immune responses. The persistence and amplification of inflammation …