[HTML][HTML] Novel subunit composition of a renal epithelial KATPChannel
A Ruknudin, DH Schulze, SK Sullivan… - Journal of Biological …, 1998 - ASBMB
Unique ATP-inhibitable K+ channels (K ATP) in the kidney determine the rate of urinary K+
excretion and play an essential role in extracellular K+ balance. Here, we demonstrate that
functionally similar low sulfonylurea affinity K ATP channels are formed by two heterologous
molecules, products of Kir1. 1a and cystic fibrosis transmembrane conductance regulator
(CFTR) genes. Co-injection of CFTR and Kir1. 1a cRNA into Xenopus oocytes lead to the
expression of K+ selective channels that retained the high open probability behavior of Kir1 …
excretion and play an essential role in extracellular K+ balance. Here, we demonstrate that
functionally similar low sulfonylurea affinity K ATP channels are formed by two heterologous
molecules, products of Kir1. 1a and cystic fibrosis transmembrane conductance regulator
(CFTR) genes. Co-injection of CFTR and Kir1. 1a cRNA into Xenopus oocytes lead to the
expression of K+ selective channels that retained the high open probability behavior of Kir1 …
