The expression of leukocyte adhesion molecules in the intact brains of mice with
experimental autoimmune encephalitis (EAE) was visualized by Magnetic Resonance
Imaging (MRI) through the use of a new, target-specific MR contrast agent. Antibody-
conjugated paramagnetic liposomes (ACPLs) were designed to achieve in vivo targeting of
molecules expressed on vascular endothelium, while providing sufficient signal
enhancement at these sites for detection by MRI. ACPLs targeted to intercellular adhesion …