[PDF][PDF] TNF-induced microvascular pathology: active role for platelets and importance of the LFA-1/ICAM-1
GE Grau, F Tacchini-Cottieri, C Vesin, G Milon… - Eur. Cytokine …, 1993 - researchgate.net
Pathogenic mechanisms of brain microvascular injury were studied in ar experimentai
model of cerebral malaria (CM). The lesion, leading to perivascular ricrohemorrhages, is
due to cytokine overproduction, and is associated wiili the se questration of macrophages
and parasitized erythrocytes in cerebral venules. In this in vivo model, we demonstrate that
platelets are critical effectors of the neurovascular injury. First, electron microscopy indicated
that during CM platelets adhere to and probably damage brain endothelial cells. Second …
model of cerebral malaria (CM). The lesion, leading to perivascular ricrohemorrhages, is
due to cytokine overproduction, and is associated wiili the se questration of macrophages
and parasitized erythrocytes in cerebral venules. In this in vivo model, we demonstrate that
platelets are critical effectors of the neurovascular injury. First, electron microscopy indicated
that during CM platelets adhere to and probably damage brain endothelial cells. Second …