[HTML][HTML] Reduced cholesterol absorption upon PPARδ activation coincides with decreased intestinal expression of NPC1L1
JN van Der Veen, JK Kruit, R Havinga, JFW Baller… - Journal of lipid …, 2005 - ASBMB
Peroxisome proliferator-activated receptors (PPARs) control the transcription of genes
involved in lipid metabolism. Activation of PPARδ may have antiatherogenic effects through
the increase of plasma HDL, theoretically promoting reverse cholesterol transport from
peripheral tissues toward the liver for removal via bile and feces. Effects of PPARδ activation
by GW610742 were evaluated in wild-type and Abca1-deficient (Abca1−/−) mice that lack
HDL. Treatment with GW610742 resulted in an∼ 50% increase of plasma HDL-cholesterol …
involved in lipid metabolism. Activation of PPARδ may have antiatherogenic effects through
the increase of plasma HDL, theoretically promoting reverse cholesterol transport from
peripheral tissues toward the liver for removal via bile and feces. Effects of PPARδ activation
by GW610742 were evaluated in wild-type and Abca1-deficient (Abca1−/−) mice that lack
HDL. Treatment with GW610742 resulted in an∼ 50% increase of plasma HDL-cholesterol …