[HTML][HTML] Peroxisome proliferator-activated receptor δ (PPARδ)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling
JB Hansen, H Zhang, TH Rasmussen… - Journal of Biological …, 2001 - ASBMB
The peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of terminal
adipocyte differentiation. PPARδ is expressed in preadipocytes, but the importance of this
PPAR subtype in adipogenesis has been a matter of debate. Here we present a critical
evaluation of the role of PPARδ in adipocyte differentiation. We demonstrate that treatment
of NIH-3T3 fibroblasts overexpressing PPARδ with standard adipogenic inducers led to
induction of PPARγ2 expression and terminal adipocyte differentiation in a manner that was …
adipocyte differentiation. PPARδ is expressed in preadipocytes, but the importance of this
PPAR subtype in adipogenesis has been a matter of debate. Here we present a critical
evaluation of the role of PPARδ in adipocyte differentiation. We demonstrate that treatment
of NIH-3T3 fibroblasts overexpressing PPARδ with standard adipogenic inducers led to
induction of PPARγ2 expression and terminal adipocyte differentiation in a manner that was …