[HTML][HTML] Nuclear factor-κB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy
A Planavila, JC Laguna, M Vázquez-Carrera - Journal of Biological …, 2005 - ASBMB
Little is known about the mechanisms responsible for the fall in fatty acid oxidation during
the development of cardiac hypertrophy. We focused on the effects of nuclear factor (NF)-κB
activation during cardiac hypertrophy on the activity of peroxisome proliferator-activated
receptor (PPAR) β/δ, which is the predominant PPAR subtype in cardiac cells and plays a
prominent role in the regulation of cardiac lipid metabolism. Phenylephrine-induced cardiac
hypertrophy in neonatal rat cardiomyocytes caused a reduction in the expression of pyruvate …
the development of cardiac hypertrophy. We focused on the effects of nuclear factor (NF)-κB
activation during cardiac hypertrophy on the activity of peroxisome proliferator-activated
receptor (PPAR) β/δ, which is the predominant PPAR subtype in cardiac cells and plays a
prominent role in the regulation of cardiac lipid metabolism. Phenylephrine-induced cardiac
hypertrophy in neonatal rat cardiomyocytes caused a reduction in the expression of pyruvate …