[HTML][HTML] The peroxisome proliferator-activated receptor δ promotes lipid accumulation in human macrophages
H Vosper, L Patel, TL Graham, GA Khoudoli… - Journal of Biological …, 2001 - ASBMB
The peroxisome proliferator-activated receptors (PPARs) are a family of fatty acid-activated
transcription factors which control lipid homeostasis and cellular differentiation. PPARα
(NR1C1) controls lipid oxidation and clearance in hepatocytes and PPARγ (NR1C3)
promotes preadipocyte differentiation and lipogenesis. Drugs that activate PPARα are
effective in lowering plasma levels of lipids and have been used in the management of
hyperlipidemia. PPARγ agonists increase insulin sensitivity and are used in the …
transcription factors which control lipid homeostasis and cellular differentiation. PPARα
(NR1C1) controls lipid oxidation and clearance in hepatocytes and PPARγ (NR1C3)
promotes preadipocyte differentiation and lipogenesis. Drugs that activate PPARα are
effective in lowering plasma levels of lipids and have been used in the management of
hyperlipidemia. PPARγ agonists increase insulin sensitivity and are used in the …