Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth
RA Gupta, D Wang, S Katkuri, H Wang, SK Dey… - Nature medicine, 2004 - nature.com
We treated Apc min mice, which are predisposed to intestinal polyposis, with a selective
synthetic agonist of peroxisome proliferator–activated receptor-δ (PPAR-δ). Exposure of Apc
min mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number
and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with
the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our
results implicate PPAR-δ in the regulation of intestinal adenoma growth.
synthetic agonist of peroxisome proliferator–activated receptor-δ (PPAR-δ). Exposure of Apc
min mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number
and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with
the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our
results implicate PPAR-δ in the regulation of intestinal adenoma growth.
Abstract
We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator–activated receptor-δ (PPAR-δ). Exposure of Apcmin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.
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