[HTML][HTML] Peroxisome proliferator-activated receptor δ is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth …
Although peroxisome proliferator-activated receptor (PPAR) δ is widely expressed in many
tissues, the role of PPARδ is poorly understood. In this study, we report that PPARδ was up-
regulated in vascular smooth muscle cells (VSMC) during vascular lesion formation. By
using Northern blot analysis, we demonstrated that PPARδ was increased by 3–4-fold in
VSMC treated with platelet-derived growth factor (PDGF)(20 ng/ml). In addition, PDGF-
induced PPARδ mRNA expression neither needs de novo protein synthesis nor affects the …
tissues, the role of PPARδ is poorly understood. In this study, we report that PPARδ was up-
regulated in vascular smooth muscle cells (VSMC) during vascular lesion formation. By
using Northern blot analysis, we demonstrated that PPARδ was increased by 3–4-fold in
VSMC treated with platelet-derived growth factor (PDGF)(20 ng/ml). In addition, PDGF-
induced PPARδ mRNA expression neither needs de novo protein synthesis nor affects the …