Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome
Y Guan - Journal of the American Society of Nephrology, 2004 - journals.lww.com
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors. Three PPAR isoforms,
designated PPARα,-β/δ, and-γ, have been identified and attracted enormous attention as a
result of the key role that these receptors play in regulating adipogenesis, lipid metabolism,
insulin sensitivity, inflammation, and BP. Growing evidence points to a causative relationship
between PPAR activity and the metabolic syndrome, including insulin resistance, glucose …
receptor superfamily of ligand-activated transcription factors. Three PPAR isoforms,
designated PPARα,-β/δ, and-γ, have been identified and attracted enormous attention as a
result of the key role that these receptors play in regulating adipogenesis, lipid metabolism,
insulin sensitivity, inflammation, and BP. Growing evidence points to a causative relationship
between PPAR activity and the metabolic syndrome, including insulin resistance, glucose …
