Distinct signaling from stem cell factor and erythropoietin in HCD57 cells
SM Jacobs-Helber, K Penta, Z Sun, A Lawson… - Journal of Biological …, 1997 - ASBMB
A recent report (Wu, H., Klingmuller, U., Besmer, P., and Lodish, HF (1995) Nature 377, 242-
246) documents the interaction of the erythropoietin (EPO) receptor (EPOR) with the stem
cell factor (SCF) receptor (c-KIT) and suggests that SCF acts through the EPOR. To elucidate
the ability of SCF to affect the erythropoietin signaling pathway, we studied the effect of SCF
on EPOR phosphorylation, SHC/ERK-1 activity, and cell proliferation and apoptosis in EPO-
dependent HCD57 cells. Treatment of these cells with SCF resulted in phosphorylation of …
246) documents the interaction of the erythropoietin (EPO) receptor (EPOR) with the stem
cell factor (SCF) receptor (c-KIT) and suggests that SCF acts through the EPOR. To elucidate
the ability of SCF to affect the erythropoietin signaling pathway, we studied the effect of SCF
on EPOR phosphorylation, SHC/ERK-1 activity, and cell proliferation and apoptosis in EPO-
dependent HCD57 cells. Treatment of these cells with SCF resulted in phosphorylation of …
