[HTML][HTML] STAT protein recruitment and activation in c-Kit deletion mutants
MF Brizzi, P Dentelli, A Rosso, Y Yarden… - Journal of Biological …, 1999 - ASBMB
Stem cell factor (SCF) and its tyrosine kinase receptor, c-Kit, play a crucial role in regulating
migration and proliferation of melanoblasts, germ cells, and hemopoietic cell progenitors by
activating a number of intracellular signaling molecules. Here we report that SCF stimulation
of myeloid cells or fibroblasts ectopically expressing c-Kit induces physical association with
and tyrosine phosphorylation of three signal transducers and activators of transcription
(STATs) as follows: STAT1α, STAT5A, and STAT5B. Other STAT proteins are not recruited …
migration and proliferation of melanoblasts, germ cells, and hemopoietic cell progenitors by
activating a number of intracellular signaling molecules. Here we report that SCF stimulation
of myeloid cells or fibroblasts ectopically expressing c-Kit induces physical association with
and tyrosine phosphorylation of three signal transducers and activators of transcription
(STATs) as follows: STAT1α, STAT5A, and STAT5B. Other STAT proteins are not recruited …
