[HTML][HTML] The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation
AM Henderson, SJ Wang, AC Taylor… - Journal of Biological …, 2001 - ASBMB
Human endothelial cells can be induced to form capillary-like tubular networks in collagen
gels. We have used thisin vitro model and representational difference analysis to identify
genes involved in the formation of new blood vessels. HESR1 (HEY-1/HRT-1/CHF-
2/gridlock), a basic helix-loop-helix protein related to the hairy/enhancer of split/HES family,
is absent in migrating and proliferating cultures of endothelial cells but is rapidly induced
during capillary-like network formation. HESR1 is detectable in all adult tissues and at high …
gels. We have used thisin vitro model and representational difference analysis to identify
genes involved in the formation of new blood vessels. HESR1 (HEY-1/HRT-1/CHF-
2/gridlock), a basic helix-loop-helix protein related to the hairy/enhancer of split/HES family,
is absent in migrating and proliferating cultures of endothelial cells but is rapidly induced
during capillary-like network formation. HESR1 is detectable in all adult tissues and at high …