Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis
C Mailhos, U Modlich, J Lewis, A Harris, R Bicknell… - Differentiation, 2001 - Elsevier
Delta-Notch signalling regulates cell-fate choices in a variety of tissues during development.
We report the expression of Delta4 (Dl4) in arterial endothelium during mouse
embryogenesis and in the endothelium of tumor blood vessels. The expression of Dl4 in the
mouse begins at 8 dpc in the dorsal aortae, umbilical artery and the heart. Subsequent
expression is restricted to smaller vessels and capillaries and is reduced in most adult
tissues. However, it is high in the vasculature of xenograft human tumors in the mouse, in …
We report the expression of Delta4 (Dl4) in arterial endothelium during mouse
embryogenesis and in the endothelium of tumor blood vessels. The expression of Dl4 in the
mouse begins at 8 dpc in the dorsal aortae, umbilical artery and the heart. Subsequent
expression is restricted to smaller vessels and capillaries and is reduced in most adult
tissues. However, it is high in the vasculature of xenograft human tumors in the mouse, in …