Notch4, a member of the Notch family of transmembrane receptors, is expressed primarily
on endothelial cells. Activation of Notch in various cell systems has been shown to regulate
cell fate decisions, partly by regulating the propensity of cells to live or die. Various studies
have demonstrated a role for Notch1 in modulating apoptosis, either in a positive or negative
manner. In this study, we determined that constitutively active Notch4 (Notch4 intracellular
domain) inhibited endothelial apoptosis triggered by lipopolysaccharide. Notch signals are …