[HTML][HTML] Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation
M Czapiga, AD Kirk, J Lekstrom-Himes - Experimental hematology, 2004 - Elsevier
The danger model of immunity and tolerance holds that antigen-presenting cells (APCs),
activated by stress, injury, or necrosis, but not by physiological (apoptotic) cell death, initiate
adaptive immune responses. APC activation is fundamentally associated with binding of
CD40 to its ligand CD154. Platelets express CD154 upon activation and are thus potential
primal danger signals linking the homeostatic response to trauma to activation of the
acquired immune system. Previously, we showed that platelets can undergo gradient-driven …
activated by stress, injury, or necrosis, but not by physiological (apoptotic) cell death, initiate
adaptive immune responses. APC activation is fundamentally associated with binding of
CD40 to its ligand CD154. Platelets express CD154 upon activation and are thus potential
primal danger signals linking the homeostatic response to trauma to activation of the
acquired immune system. Previously, we showed that platelets can undergo gradient-driven …