Toll-like receptor 2-dependent and-independent activation of macrophages by group B streptococci
DW Draper, HN Bethea, YW He - Immunology letters, 2006 - Elsevier
Group B streptococcus (GBS), a capsulated gram-positive bacterium, is a major cause of
newborn infections. Although the innate immune receptor Toll-like receptor (TLR) 2 has
been shown to primarily recognize gram-positive bacterial products, the production of TNF
by macrophages treated with heat-killed GBS (HK-GBS) does not depend on TLR2. In this
report, we have characterized HK-GBS-induced activation of macrophages derived from
wildtype and TLR2-deficient mice. Microarray analysis demonstrated that HK-GBS activation …
newborn infections. Although the innate immune receptor Toll-like receptor (TLR) 2 has
been shown to primarily recognize gram-positive bacterial products, the production of TNF
by macrophages treated with heat-killed GBS (HK-GBS) does not depend on TLR2. In this
report, we have characterized HK-GBS-induced activation of macrophages derived from
wildtype and TLR2-deficient mice. Microarray analysis demonstrated that HK-GBS activation …