PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression
Prostate cancer, the most frequent solid cancer in older men, is a leading cause of cancer
deaths. Although proliferation and differentiation of normal prostate epithelia and the initial
growth of prostate cancer cells are androgen-dependent, prostate cancers ultimately
become androgen-independent and refractory to hormone therapy. The prostate-specific
antigen (PSA) gene has been widely used as a diagnostic indicator for androgen-dependent
and-independent prostate cancer. Androgen-induced and prostate epithelium-specific PSA …
deaths. Although proliferation and differentiation of normal prostate epithelia and the initial
growth of prostate cancer cells are androgen-dependent, prostate cancers ultimately
become androgen-independent and refractory to hormone therapy. The prostate-specific
antigen (PSA) gene has been widely used as a diagnostic indicator for androgen-dependent
and-independent prostate cancer. Androgen-induced and prostate epithelium-specific PSA …
