[HTML][HTML] Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTRΔ508 in the lung
Cystic fibrosis (CF), a common lethal pulmonary disorder in Caucasians, is caused by
mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) that
disturbs fluid homeostasis and host defense in target organs. The effects of CFTR and Δ508-
CFTR were assessed in transgenic mice that 1) lack CFTR expression (Cftr-/-); 2) express
the human Δ508 CFTR (CFTR Δ508); 3) overexpress the normal human CFTR (CFTR tg) in
respiratory epithelial cells. Genes were selected from Affymetrix Murine Gene-Chips …
mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) that
disturbs fluid homeostasis and host defense in target organs. The effects of CFTR and Δ508-
CFTR were assessed in transgenic mice that 1) lack CFTR expression (Cftr-/-); 2) express
the human Δ508 CFTR (CFTR Δ508); 3) overexpress the normal human CFTR (CFTR tg) in
respiratory epithelial cells. Genes were selected from Affymetrix Murine Gene-Chips …
