It has been shown that adoptively transferred adult neural stem cells (NSCs) ameliorate
experimental autoimmune encephalomyelitis (EAE) by differentiating into myelin-forming
cells. However, NSC migration into the lesion foci is inefficient and relatively slow, resulting
in only modest therapeutic effect. A possible reason for the inefficient migration of NSCs
could be the production of anti-inflammatory cytokines by these cells, which might in turn
suppress their migration. To address this question we established subventricular zone …