Loss of Sprouty1 rescues renal agenesis caused by Ret mutation
EJ Rozen, H Schmidt, X Dolcet… - Journal of the …, 2009 - journals.lww.com
Renal morphogenesis requires a balance between positive and negative signals, which are
provided in part by the receptor tyrosine kinase Ret and the putative tumor suppressor
Sprouty1, respectively. Tyrosine 1062 of Ret is a binding site for several adaptor and effector
proteins, such as Grb2/Sos/Ras, which activate the ERK pathway. Mice lacking Ret tyrosine
1062 nearly mimic the phenotype of Ret-knockout mice, which includes renal agenesis.
Sprouty1 regulates Ret activity by modulating the ERK pathway, but the mechanism by …
provided in part by the receptor tyrosine kinase Ret and the putative tumor suppressor
Sprouty1, respectively. Tyrosine 1062 of Ret is a binding site for several adaptor and effector
proteins, such as Grb2/Sos/Ras, which activate the ERK pathway. Mice lacking Ret tyrosine
1062 nearly mimic the phenotype of Ret-knockout mice, which includes renal agenesis.
Sprouty1 regulates Ret activity by modulating the ERK pathway, but the mechanism by …
