Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2−/− mouse model
J Hecht, V Seitz, M Urban, F Wagner… - Gene Expression …, 2007 - Elsevier
Runx2 is an essential factor for skeletogenesis and heterozygous loss causes cleidocranial
dysplasia in humans and a corresponding phenotype in the mouse. Homozygous Runx2-
deficient mice lack hypertrophic cartilage and bone. We compared the expression profiles of
E14. 5 wildtype and Runx2−/− murine embryonal humeri to identify new transcripts
potentially involved in cartilage and bone development. Seventy-one differentially
expressed genes were identified by two independent oligonucleotide-microarray …
dysplasia in humans and a corresponding phenotype in the mouse. Homozygous Runx2-
deficient mice lack hypertrophic cartilage and bone. We compared the expression profiles of
E14. 5 wildtype and Runx2−/− murine embryonal humeri to identify new transcripts
potentially involved in cartilage and bone development. Seventy-one differentially
expressed genes were identified by two independent oligonucleotide-microarray …
