Histone-modifying enzymes: encrypting an enigmatic epigenetic code
JF Couture, RC Trievel - Current opinion in structural biology, 2006 - Elsevier
JF Couture, RC Trievel
Current opinion in structural biology, 2006•ElsevierHistone-modifying enzymes catalyze a diverse array of post-translational modifications of
core and linker histones within chromatin. These modifications govern a multitude of
genomic functions, particularly gene expression, and are believed to constitute an
epigenetic code. Histone-modifying enzymes inscribe this code by catalyzing site-selective
modifications, which are subsequently interpreted by effector proteins that recognize specific
covalent marks. The substrate specificity of these enzymes is of fundamental biological …
core and linker histones within chromatin. These modifications govern a multitude of
genomic functions, particularly gene expression, and are believed to constitute an
epigenetic code. Histone-modifying enzymes inscribe this code by catalyzing site-selective
modifications, which are subsequently interpreted by effector proteins that recognize specific
covalent marks. The substrate specificity of these enzymes is of fundamental biological …
Histone-modifying enzymes catalyze a diverse array of post-translational modifications of core and linker histones within chromatin. These modifications govern a multitude of genomic functions, particularly gene expression, and are believed to constitute an epigenetic code. Histone-modifying enzymes inscribe this code by catalyzing site-selective modifications, which are subsequently interpreted by effector proteins that recognize specific covalent marks. The substrate specificity of these enzymes is of fundamental biological importance because it underpins this epigenetic code. Recently, the structural basis of this specificity has been examined with regards to recently determined structures of GCN5 acetyltransferases and SET domain methyltransferases in complex with their cognate histone substrates.
Elsevier