Neurosensory mechanotransduction
M Chalfie - Nature reviews Molecular cell biology, 2009 - nature.com
M Chalfie
Nature reviews Molecular cell biology, 2009•nature.comNeurons that sense touch, sound and acceleration respond rapidly to specific mechanical
signals. The proteins that transduce these signals and underlie these senses, however, are
mostly unknown. Research over the past decade has suggested that members of three
families of channel proteins are candidate transduction molecules. Current studies are
directed towards characterizing these candidates, determining how they are mechanically
gated and discovering new molecules that are involved in mechanical sensing.
signals. The proteins that transduce these signals and underlie these senses, however, are
mostly unknown. Research over the past decade has suggested that members of three
families of channel proteins are candidate transduction molecules. Current studies are
directed towards characterizing these candidates, determining how they are mechanically
gated and discovering new molecules that are involved in mechanical sensing.
Abstract
Neurons that sense touch, sound and acceleration respond rapidly to specific mechanical signals. The proteins that transduce these signals and underlie these senses, however, are mostly unknown. Research over the past decade has suggested that members of three families of channel proteins are candidate transduction molecules. Current studies are directed towards characterizing these candidates, determining how they are mechanically gated and discovering new molecules that are involved in mechanical sensing.
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