[HTML][HTML] Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration
Interleukin-6 (IL-6) via its signal transducer gp130 is an important mediator of liver
regeneration involved in protecting from lipopolysaccharide (LPS)-induced liver injury after
partial hepatectomy (PH). Here we generated mice either defective (Δ) in hepatocyte-
specific gp130-dependent Ras or STAT activation to define their role during liver
regeneration. Deletion of gp130-dependent signaling had major impact on acute phase
gene (APG) regulation after PH. APG expression was blocked in gp130-ΔSTAT animals …
regeneration involved in protecting from lipopolysaccharide (LPS)-induced liver injury after
partial hepatectomy (PH). Here we generated mice either defective (Δ) in hepatocyte-
specific gp130-dependent Ras or STAT activation to define their role during liver
regeneration. Deletion of gp130-dependent signaling had major impact on acute phase
gene (APG) regulation after PH. APG expression was blocked in gp130-ΔSTAT animals …