[HTML][HTML] Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
H Saitoh, J Hinchey - Journal of Biological Chemistry, 2000 - ASBMB
Post-translational modification marked by the covalent attachment of the ubiquitin-like
protein SUMO-1/SMT3C has been implicated in a wide variety of cellular processes.
Recently, two cDNAs encoding proteins related to SUMO-1 have been identified in human
and mouse. The functions and regulation of these proteins, known as SUMO-2/SMT3A and
SUMO-3/SMT3B, remain largely uncharacterized. We describe herein quantitative and
qualitative distinctions between SUMO-1 and SUMO-2/3 in vertebrate cells. Much of this was …
protein SUMO-1/SMT3C has been implicated in a wide variety of cellular processes.
Recently, two cDNAs encoding proteins related to SUMO-1 have been identified in human
and mouse. The functions and regulation of these proteins, known as SUMO-2/SMT3A and
SUMO-3/SMT3B, remain largely uncharacterized. We describe herein quantitative and
qualitative distinctions between SUMO-1 and SUMO-2/3 in vertebrate cells. Much of this was …