TLR signalling regulated antigen presentation in dendritic cells
C Watts, MA West, R Zaru - Current opinion in immunology, 2010 - Elsevier
C Watts, MA West, R Zaru
Current opinion in immunology, 2010•ElsevierRecent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances
antigen endocytosis and autophagy, augments the assembly of key antigen transport and
processing systems, qualitatively modulates protein translation and induces a temporary
cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-
kinase and downstream signalling pathways and are observed in both myeloid DC and, with
variations on the theme, in plasmacytoid DC.
antigen endocytosis and autophagy, augments the assembly of key antigen transport and
processing systems, qualitatively modulates protein translation and induces a temporary
cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-
kinase and downstream signalling pathways and are observed in both myeloid DC and, with
variations on the theme, in plasmacytoid DC.
Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.
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