[HTML][HTML] Tumor necrosis factor inhibits glucocorticoid receptor function in mice: a strong signal toward lethal shock
T Van Bogaert, S Vandevyver, L Dejager… - Journal of Biological …, 2011 - ASBMB
As glucocorticoid resistance (GCR) and the concomitant burden pose a worldwide problem,
there is an urgent need for a more effective glucocorticoid therapy, for which insights into the
molecular mechanisms of GCR are essential. In this study, we addressed the hypothesis that
TNFα, a strong pro-inflammatory mediator in numerous inflammatory diseases,
compromises the protective function of the glucocorticoid receptor (GR) against TNFα-
induced lethal inflammation. Indeed, protection of mice by dexamethasone against TNFα …
there is an urgent need for a more effective glucocorticoid therapy, for which insights into the
molecular mechanisms of GCR are essential. In this study, we addressed the hypothesis that
TNFα, a strong pro-inflammatory mediator in numerous inflammatory diseases,
compromises the protective function of the glucocorticoid receptor (GR) against TNFα-
induced lethal inflammation. Indeed, protection of mice by dexamethasone against TNFα …
