Tumor Necrosis Factor ä-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase …
MA Read, MZ Whitley, S Gupta, JW Pierce… - Journal of Biological …, 1997 - ASBMB
E-selectin expression by endothelium is crucial for leukocyte recruitment during
inflammatory responses. Transcriptional regulation of the E-selectin promoter by tumor
necrosis factor ä (TNFä) requires multiple nuclear factor-κB (NF-κB) binding sites and a
cAMP-responsive element/activating transcription factor-like binding site designated positive
domain II (PDII). Here we characterize the role of the stress-activated family of mitogen-
activated protein (MAP) kinases in induced expression of this adhesion molecule. By UV …
inflammatory responses. Transcriptional regulation of the E-selectin promoter by tumor
necrosis factor ä (TNFä) requires multiple nuclear factor-κB (NF-κB) binding sites and a
cAMP-responsive element/activating transcription factor-like binding site designated positive
domain II (PDII). Here we characterize the role of the stress-activated family of mitogen-
activated protein (MAP) kinases in induced expression of this adhesion molecule. By UV …
