[HTML][HTML] Selective inhibition of protein kinase C isozymes by Fas ligation
CY Chen, DV Faller - Journal of Biological Chemistry, 1999 - ASBMB
Activation of protein kinase C (PKC) can protect cells from apoptosis induced by various
agents, including Fas ligation. To elucidate a possible interaction between Fas-mediated
apoptotic signals and activation-related protective signals, we investigated the impact of Fas
ligation on PKC activity. We demonstrate that engagement of Fas on human lymphoid Jurkat
cells triggered apoptosis, and Fas ligation resulted in partial blockade of cellular PKC
activity. The phorbol 12-myristate 13-acetate-mediated translocation of PKCθ from the …
agents, including Fas ligation. To elucidate a possible interaction between Fas-mediated
apoptotic signals and activation-related protective signals, we investigated the impact of Fas
ligation on PKC activity. We demonstrate that engagement of Fas on human lymphoid Jurkat
cells triggered apoptosis, and Fas ligation resulted in partial blockade of cellular PKC
activity. The phorbol 12-myristate 13-acetate-mediated translocation of PKCθ from the …
