Early experiments have shown that sustained elevation of diacylglycerol (DAG) level in liver
cell plasma membranes of aged rats is an essential prerequisite for disturbances in agonist
responsiveness of hepatocytes. However, the mechanisms responsible for the age-related
rise in DAG content in liver cells have not been clearly identified. The aim of the present
study was to determine if phospholipid degradation by endogenous phospholipases
precedes the DAG accumulation in liver cells and cell nuclei. The DAG formation in liver …